Article
Molecular analysis of the Oka vaccine strain of varicella-zoster virus.
The Journal of infectious diseases - 1 Mar 2008
Yamanishi Koichi
Abstract excerpt
Live attenuated Oka vaccine was subjected to molecular analysis, with the long-term goal of identifying genes in the vaccine strain responsible for its attenuation. Complete genomic sequences for both the Oka parent virus and the Oka vaccine virus were determined and compared. There were differences in only 42 bases between the 2 viruses. More than one-third (15/42) of the nucleotide substitutions in V-Oka were...
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