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Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence

21 May 2018

Abstract excerpt

Physical properties of modifiable hydrogels can be tuned to direct stem cell differentiation in a role akin to that played by the extracellular matrix in native stem cell niches. However, stem cells do not respond to matrix cues in isolation, but rather integrate soluble and non-soluble signals to balance quiescence, self-renewal and differentiation. Here, we encapsulated single cell suspensions of human...

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PMID: 29852376
DOI: 10.1016/j.biomaterials.2018.05.032

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