Article
IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity.
Mediators of inflammation - 1 Jan 2018
Singh HariOm, Samani Dharmesh, Nema Vijay, Ghate Manisha V, Gangakhedkar R R
Abstract excerpt
The severity of hepatic injury depends upon cytokines. Previous studies associated IL-1RN allele 2 with IL-1β production. Hence, we examined the association of IL-1 RN and IL-1β polymorphisms with ARV-associated hepatotoxicity. Genotyping of IL-1RN (VNTR), IL-1β (-511C/T) polymorphisms was done in 162 HIV-infected patients, 34 with ARV hepatotoxicity, 128 without hepatotoxicity, and 152 healthy controls using PCR...
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