ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.

doi:10.1002/mgg3.2362

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Article

ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.

Molecular genetics & genomic medicine - 1 Mar 2024

Singh HariOm, Dhotre Kishore, Shyamveer, Choudhari Ranjana, Verma Amita, Mahajan Supriya D, Ali Nemat

Abstract excerpt

BACKGROUND: The ABCG2 421C/A polymorphism contributes significantly to the distribution and absorption of antiretroviral (ARV) regimens and is associated with the undesirable side effects of efavirenz. METHODS: To investigate this, we examined ABCG2 34G/A (rs2231137) and 421C/A (rs2231142) genetic variations in 149 HIV-infected patients (116 without hepatotoxicity, 33 with ARV-induced hepatotoxicity) and 151...

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PMID: 38451012
DOI: 10.1002/mgg3.2362
PMCID: PMC10955225

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