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Article

Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption.

Cancer letters - 1 Sept 2018

Hu Yabin, Zhou Yan, Yang Gaoxiang, Wang Yalin, Zheng Zhongnan, Li Juntao, Yan Yuting, Wu Wei

Abstract excerpt

Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a potential drug to inhibit human non-small cell lung cancer (NSCLC), but the underlying mechanisms are elusive. Here, we uncovered that SFN-NAC induced apoptosis via flow cytometer assay and transmission electron microscopy. Further, SFN-NAC increased LC3 II/LC3 I and the number of LC3 punctas, but Western blot showed that SFN-NAC inhibited cell autophagy in response...

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Identifiers

PMID: 29807114
DOI: 10.1016/j.canlet.2018.05.035

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SFN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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