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Article

Sulforaphane overcomes T790M-mediated gefitinib resistance in vitro through epithelial-mesenchymal transition.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Oct 2021

Meng W, Meng J, Zhang F, Jiang H, Feng X, Zhao F, Wang K

Abstract excerpt

The purpose of the present study was to investigate the effects of sulforaphane (SFN) on gefitinib-resistant cell lines with a T790 mutation (PC-9/AB11). The PC-9 and PC-9/AB11 cells were stained with H&E and visualized with a light microscope. The CCK-8 assay method was used to evaluate the antiproliferative activity of gefitinib and SFN on the cells. Cell cycle arrest and apoptosis were analyzed via flow...

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Identifiers

PMID: 35158336
DOI: 10.26402/jpp.2021.5.09

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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