Article
Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity.
Annals of the rheumatic diseases - 1 May 2009
Martens H A, Zuurman M W, de Lange A H M, Nolte I M, van der Steege G, Navis G J, Kallenberg C G M, Seelen M A, Bijl M
Abstract excerpt
BACKGROUND: Several findings link systemic lupus erythematosus (SLE) with C1q, the first molecule of the classical complement pathway. Polymorphisms of the C1qA gene are associated with low serum C1q levels in patients with cutaneous LE, but C1q polymorphisms have not been studied in patients with systemic lupus. OBJECTIVE: To determine whether polymorphisms of the C1q genes are associated with SLE, disease...
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