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Article

Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism.

Molecular oncology - 1 Jun 2018

Cho Young-Ra, Lee Ji Hyeon, Kim Ji Hye, Lee So-Yeon, Yoo Suna, Jung Min-Kyo, Kim Su Jung, Yoo Hyun Ju, Pack Chang-Gi, Rho Jin Kyung, Son Jaekyoung

Abstract excerpt

Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers without any obvious side effects; however, the molecular mechanisms of its antiproliferative effects on cancer are unclear. Here, we report that matrine inhibits...

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Source

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Identifiers

PMID: 29791786
DOI: 10.1002/1878-0261.12324
PMCID: PMC6026868

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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