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Article

Effects of immuno-related gene polymorphisms on a bispecific antibody targeting colorectal cancer cell.

Personalized medicine - 1 May 2018

Zhang Cong-Min, Yu Lin-Yu, Lv Jin-Feng, Gong Liang, Zhou Hong-Hao, Chen Xiao-Ping, Fan Lan

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells. AIM: To investigate the influence of immuno-related gene polymorphisms on M701 mediated cytotoxicity to CRC cell HCT116. METHOD: We analyzed the influence of the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29790821
DOI: 10.2217/pme-2017-0071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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