Article
Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.
International journal of epidemiology - 1 Oct 2019
Jiang Xia, Dimou Niki L, Al-Dabhani Kawthar, Lewis Sarah J, Martin Richard M, Haycock Philip C, Gunter Marc J, Key Timothy J, Eeles Rosalind A, Muir Kenneth, Neal David, Giles Graham G, Giovannucci Edward L, Stampfer Meir, Pierce Brandon L, Schildkraut Joellen M, Warren Andersen Shaneda, Thompson Deborah, Zheng Wei, Kraft Peter, Tsilidis Konstantinos K
Abstract excerpt
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15 748 breast and 22 898 prostate-cancer cases. Demonstrating causality has proven challenging and one common limitation of MR studies is insufficient power. METHODS: We...
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