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Article

SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer

21 May 2018

Abstract excerpt

Abstract Reprogramming of cellular metabolism is an important feature of prostate cancer, including altered lipid metabolism. Recently, it was observed that the nuclear fraction of mTOR is essential for the androgen-mediated metabolic reprogramming of prostate cancer cells. Herein, it is demonstrated that the androgen receptor (AR) and mTOR bind to regulatory regions of sterol regulatory element-binding...

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Share to Cancer, Lipids, and Metabolism
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PMID: 29784665
DOI: 10.1158/1541-7786.mcr-17-0410

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