Article
Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.
Tuberculosis (Edinburgh, Scotland) - 1 May 2018
Feliciano Cinara Silva, Namburete Evangelina Inacio, Rodrigues Plaça Jéssica, Peronni Kamila, Dippenaar Anzaan, Warren Robin Mark, Silva Wilson Araújo, Bollela Valdes Roberto
Abstract excerpt
BACKGROUND: The fast and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is critical to reducing the spread of disease. Although commercial genotypic drug-susceptibility tests (DST) are close to the goal, they are still not able to detect all relevant DR-TB related mutations. Whole genome sequencing (WGS) allows better comprehension of DR-TB with a great discriminatory power. We aimed to evaluate WGS in...
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