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Article

Emerging strategies in BRCA-positive pancreatic cancer.

Journal of cancer research and clinical oncology - 1 Aug 2018

Kowalewski Adam, Szylberg Łukasz, Saganek Michał, Napiontek Wojciech, Antosik Paulina, Grzanka Dariusz

Abstract excerpt

PURPOSE: We propose a treatment algorithm for PDAC with particular emphasis on BRCA1 or 2 mutation-positive patients. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases in the United States and Europe. BRCA1 and BRCA2 are among the most common of the known genetic mutations involved in familial PDAC. The optimal chemotherapy regimen to use for BRCA1 or 2 mutation carriers with PDAC is not...

Topics

Carcinoma, Pancreatic Ductal
Genes, BRCA1
Genes, BRCA2
Humans
Mutation
Pancreatic Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29777302
DOI: 10.1007/s00432-018-2666-9
PMCID: PMC6061050

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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