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Article

Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway.

Journal of cellular physiology - 1 Jun 2007

Tumbarello David A, Turner Christopher E

Abstract excerpt

Epithelial-mesenchymal transformation (EMT) in response to TGFbeta1 is a coordinated process of tissue morphogenesis that occurs during embryonic development as well as during certain pathologic events including kidney tubulointerstitial fibrosis. It is characterized by the disassembly of cell-cell junctions and dramatic alterations in the actin cytoskeleton that facilitates cell-matrix adhesion and stimulates...

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Identifiers

PMID: 17299801
DOI: 10.1002/jcp.20991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway.PMID 17299801Read ↗

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