Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity

Abstract excerpt

Abstract Cell–cell and cell–matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell–cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA‐ROCK signaling to maintain an active...

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