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Article

Attachment of phosphorylcholine residues to pneumococcal teichoic acids and modification of substitution patterns by the phosphorylcholine esterase.

The Journal of biological chemistry - 6 Jul 2018

Waldow Franziska, Kohler Thomas P, Hess Nathalie, Schwudke Dominik, Hammerschmidt Sven, Gisch Nicolas

Abstract excerpt

The bacterial lung pathogen Streptococcus pneumoniae has a unique nutritional requirement for exogenous choline and attaches phosphorylcholine (P-Cho) residues to the GalpNAc moieties of its teichoic acids (TAs) in its cell wall. Two phosphorylcholine transferases, LicD1 and LicD2, mediate the attachment of P-Cho to the O-6 positions of the two GalpNAc residues present in each repeating unit of pneumococcal TAs...

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Identifiers

PMID: 29764936
DOI: 10.1074/jbc.RA118.003360
PMCID: PMC6036202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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