Article
Mutation analysis of the WNT7A gene in patients with schizophrenia.
Psychiatry research - 1 Jul 2018
Hu Tsung-Ming, Ping Lieh-Yung, Hsu Shih-Hsin, Tsai Hsin-Yao, Cheng Min-Chih
Abstract excerpt
Aberrant WNT signaling has been implicated in the pathophysiology of schizophrenia. WNT7A, a member of the WNT gene family, is considered a potential candidate of schizophrenia. All exons of WNT7A in 570 schizophrenic patients and 563 controls were sequenced, and protein functional analysis was conducted. Five common variants were identified, but none were noted to be associated with schizophrenia. Nevertheless,...
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