Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase.

Nature structural biology - 1 Sept 2000

Jez J M, Bowman M E, Dixon R A, Noel J P

Abstract excerpt

Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcone synthesized by chalcone synthase (CHS) into (2S)-naringenin, an essential compound in the biosynthesis of anthocyanin pigments, inducers of Rhizobium nodulation genes, and antimicrobial phytoalexins. The 1.85 A resolution crystal structure of alfalfa CHI in complex with (2S)-naringenin reveals a novel open-faced beta-sandwich fold....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclization
Share to Diffusion
Share to Flavanones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flavonoids

Share to Intramolecular Lyases

Share to Medicago sativa

Share to Multienzyme Complexes

Share to Stereoisomerism

Source

Identifiers

PMID: 10966651
DOI: 10.1038/79025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase.PMID 10966651Read ↗

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.Semantic proximity Read ↗

Evolution of chalcone isomerase from a noncatalytic ancestor.Semantic proximity Read ↗

Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids.Semantic proximity Read ↗

CcCHIL, a type IV chalcone isomerase that can improve (2S)-naringenin production in Saccharomyces cerevisiaeSemantic proximity Read ↗

Functional Promiscuity of Two Divergent Paralogs of Type III Plant Polyketide Synthases.Semantic proximity Read ↗

Elusive partners: a review of the auxiliary proteins guiding metabolic flux in flavonoid biosynthesis.Semantic proximity Read ↗

Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis.Semantic proximity Read ↗

Chalcone-Synthase-Encoding RdCHS1 Is Involved in Flavonoid Biosynthesis in Rhododendron delavayi.Semantic proximity Read ↗

Duplication and adaptive evolution of the chalcone synthase genes of Dendranthema (Asteraceae).Semantic proximity Read ↗

Ectopic expression and functional characterization of type III polyketide synthase mutants from Emblica officinalis Gaertn.Semantic proximity Read ↗

Flavonoid components and flower color change in transgenic tobacco plants by suppression of chalcone isomerase gene.Semantic proximity Read ↗

Functional diversification of duplicated chalcone synthase genes in anthocyanin biosynthesis of Gerbera hybrida.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.