Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle

Abstract excerpt

Apobec2 is a member of the activation‐induced deaminase/apolipoprotein B mRNA editing enzyme catalytic polypeptide cytidine deaminase family expressed in differentiated skeletal and cardiac muscle. We previously reported that Apobec2 deficiency in mice leads to a shift in muscle fiber type, myopathy, and diminished muscle mass. However, the mechanisms of myopathy caused by Apobec2 deficiency and its physiologic...

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