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Article

FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness.

Cell death & disease - 11 May 2018

Yuan Bowen, Liu Youhong, Yu Xiaohui, Yin Linglong, Peng Yuchong, Gao Yingxue, Zhu Qianling, Cao Tuoyu, Yang Yinke, Fan Xuegong, Li Xiong

Abstract excerpt

Therapy-induced expansion of cancer stem cells (CSCs) has been identified as one of the most critical factors contributing to therapeutic resistance, but the mechanisms of this adaptation are not fully understood. UHRF1 is a key epigenetic regulator responsible for therapeutic resistance, and controls the self-renewal of stem cells. In the present study, taxane-resistant cancer cells were established and...

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Source

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Identifiers

PMID: 29752436
DOI: 10.1038/s41419-018-0631-9
PMCID: PMC5948215

Genes

FOXM1
UHRF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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