Article
mRNA expression profile in peripheral blood mononuclear cells based on ADRB1 Ser49Gly and Arg389Gly polymorphisms in essential hypertension - a case-control pilot investigation in South Indian population.
Clinical chemistry and laboratory medicine - 26 Jul 2018
Varakantham Varsha, Kurakula Sailoo Ashok Kumar, Nagalla Balakrishna, Bharatraj Dinesh Kumar
Abstract excerpt
BACKGROUND: β1-Adrenoreceptor (ADRB1) genetic polymorphisms are widely studied for susceptibility to many cardiovascular diseases such as essential hypertension. However, the mRNA expression of ADRB1 is rarely studied. METHODS: A case-control pilot study with 292 hypertensives and 324 controls was designed to evaluate the role of the Ser49Gly and Arg389Gly, which are commonly studied single nucleotide...
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