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Genomic features of renal cell carcinoma with venous tumor thrombus

4 May 2018

Abstract excerpt

A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of viable tumor cells, we applied multiregion whole exome sequencing to a total of 37 primary tumor and VTT samples including normal tissue specimens from five consecutive...

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PMID: 29748622
DOI: 10.1038/s41598-018-25544-z

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