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Article

Tailored Adjunctive Cilostazol Therapy Based on CYP2C19 Genotyping in Patients With Acute Myocardial Infarction　- The CALDERA-GENE Study.

Circulation journal : official journal of the Japanese Circulation Society - 25 May 2018

Kaikita Koichi, Yoshimura Hiromi, Ishii Masanobu, Kudoh Takashi, Yamada Yoshihiro, Yamamoto Eiichiro, Izumiya Yasuhiro, Kojima Sunao, Shimomura Hideki, Tsunoda Ryusuke, Matsui Kunihiko, Ogawa Hisao, Tsujita Kenichi

Abstract excerpt

BACKGROUND: Patients with reduced-function CYP2C19 genotypes on dual antiplatelet therapy (DAPT) with aspirin and clopidogrel show higher clinical risk for acute myocardial infarction (AMI). We investigated the effect of CYP2C19 genotype-tailored adjunctive cilostazol therapy on treatment of AMI. METHODS AND RESULTS: The study group of 138 patients with suspected AMI were screened for CYP2C19 genotype immediately...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29743380
DOI: 10.1253/circj.CJ-18-0197

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