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Article

Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate.

Journal of medicinal chemistry - 14 Jun 2018

Broecker Felix, Götze Sebastian, Hudon Jonathan, Rathwell Dominea C K, Pereira Claney L, Stallforth Pierre, Anish Chakkumkal, Seeberger Peter H

Abstract excerpt

Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic vaccines against infectious diseases as well as cancer. Here, we present a two-component platform based on the facile conjugation of carbohydrate antigens to α-galactosylceramide (α-GalCer) to yield fully synthetic vaccine candidates. Formulation of the cancer-associated Tn antigen glycolipid model vaccine candidate into...

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Share to Antigens, Tumor-Associated, Carbohydrate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29742893
DOI: 10.1021/acs.jmedchem.8b00312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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