Article
Mutated cancer autoantigen implicated cause of paraneoplastic myasthenia gravis.
Muscle & nerve - 1 Oct 2018
Zekeridou Anastasia, Griesmann Guy E, Lennon Vanda A
Abstract excerpt
INTRODUCTION: Antitumor immune responses are postulated to initiate paraneoplastic neurological disorders when proteins that are normally restricted to neural cells are expressed as oncoproteins. Mutated oncopeptides could bypass self-tolerant T cells to activate cytotoxic effector T lymphocytes and requisite helper T lymphocytes to stimulate autoantibody production by B lymphocytes. METHODS: We investigated...
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