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Article

Evolution of adrenoleukodystrophy model systems.

Journal of inherited metabolic disease - 1 May 2021

Montoro Roberto, Heine Vivi M, Kemp Stephan, Engelen Marc

Abstract excerpt

X-linked adrenoleukodystrophy (ALD) is a neurometabolic disorder affecting the adrenal glands, testes, spinal cord and brain. The disease is caused by mutations in the ABCD1 gene resulting in a defect in peroxisomal degradation of very long-chain fatty acids and their accumulation in plasma and tissues. Males with ALD have a near 100% life-time risk to develop myelopathy. The life-time prevalence to develop...

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Identifiers

PMID: 33373044
DOI: 10.1002/jimd.12357
PMCID: PMC8248356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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