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Article

Genetic analysis of the X-linked adrenoleukodystrophy gene ABCD1 in Drosophila uncovers a conserved phenotype.

Communications biology - 7 May 2026

Manor Joshua, Jangam Sharayu V, Chung Hyung-Lok, Bhagwat Pranjali, Andrews Jonathan C, Chester Hillary, Kondo Shu, Srivastav Saurabh, Botas Juan, Moser Ann B, Huguenin Suzette M, Wangler Michael F

Abstract excerpt

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients,...

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Identifiers

PMID: 42098404
DOI: 10.1038/s42003-026-10109-y
PMCID: PMC13357584

Genes

ABCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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