Article
Integrative multi-omics analysis of growth plate regulation underlying body size in miniature pigs.
Communications biology - 30 Jun 2026
Khaveh Nadia, Berghöfer Jan, Ralph Brehm, Buschow René, Cirksena Karsten, Drögemüller Cord, Fatima Abeera, Grabert Gordon, Gerold Gisa, Grahofer Alexander, Herwig Ralf, Jung Klaus, Kacprowski Tim, Lo Bai-Wei, Shiasi Sardoabi Roya, Vingron Martin, Mundlos Stefan, Metzger Julia
Abstract excerpt
Body size represents a complex phenotype driven by genetic variation and epigenetic regulation, with the molecular processes underlying this trait remaining a central challenge to disentangle. To elucidate these fundamental mechanisms, we apply a multi-omics approach that combines ROH-based selection mapping with growth plate epigenomics in pigs. Taking advantage of divergent selection that separates pigs into...
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