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Untying the gordion knot of targeting MET in cancer.

Cancer treatment reviews - 1 May 2018

Raghav Kanwal, Bailey Ann Marie, Loree Jonathan M, Kopetz Scott, Holla Vijaykumar, Yap Timothy Anthony, Wang Fang, Chen Ken, Salgia Ravi, Hong David

Abstract excerpt

Despite compelling evidence backing the crucial role of a dysregulated MET axis in cancer and a myriad of agents targeting this pathway in active clinical development, the therapeutic value of MET inhibition in cancer oncology remains to be established. Although a series of disappointing clinical trials, at first, lessened fervor for targeting this pathway, investigations continue unabated with a number of novel...

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Identifiers

PMID: 29730462
DOI: 10.1016/j.ctrv.2018.04.008

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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