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Article

Case-control study on PCSK9 R496W (rs374603772) and D374Y (rs137852912) mutations in Turkish patients with primary dyslipidemia.

Anatolian journal of cardiology - 1 May 2018

Eroğlu Zuhal, Tetik Vardarlı Aslı, Düzgün Zekeriya, Gündüz Cumhur, Bozok Çetintaş Vildan, Kayıkçıoğlu Meral

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the relationships between F216L (rs28942112), R496W (rs374603772), S127R (rs28942111), and D374Y (rs137852912) PCSK9 gain-of-function (GOF) mutations and primary dyslipidemia and serum lipid levels in patients with primary dyslipidemia. METHODS: In this case-control study, DNA was isolated from blood samples collected from patients diagnosed with primary...

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Source

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Identifiers

PMID: 29724976
DOI: 10.14744/AnatolJCardiol.2018.86648
PMCID: PMC6280272

Genes

PCSK9

Variants

rs374603772
rs374603772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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