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Functional analysis of PCSK9 3'UTR variants and mRNA-miRNA interactions in patients with familial hypercholesterolemia.

Epigenomics - 1 May 2021

Los Bruna, Borges Jéssica B, Oliveira Victor F, Freitas Renata Cc, Dagli-Hernandez Carolina, Bortolin Raul H, Gonçalves Rodrigo M, Faludi André A, Rodrigues Alice C, Bastos Gisele M, Jannes Cinthia E, Pereira Alexandre C, Hirata Rosario Dc, Hirata Mario H

Abstract excerpt

Aim: Functional analysis of PCSK9 3'UTR variants and mRNA-miRNA interactions were explored in patients with familial hypercholesterolemia (FH). Materials & methods:PCSK9 3'UTR variants were identified by exon-targeted gene sequencing. Functional effects of 3'UTR variants and mRNA-miRNA interactions were analyzed using in silico and in vitro studies in HEK293FT and HepG2 cells. Results: Twelve PCSK9 3'UTR variants...

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PMID: 33899508
DOI: 10.2217/epi-2020-0462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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