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Article

Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias.

Circulation research - 2 Mar 2012

Denegri Marco, Avelino-Cruz José Everardo, Boncompagni Simona, De Simone Stefano Andrea, Auricchio Alberto, Villani Laura, Volpe Pompeo, Protasi Feliciano, Napolitano Carlo, Priori Silvia Giuliana

Abstract excerpt

RATIONALE: Catecholaminergic polymorphic ventricular tachycardia is an inherited disease that predisposes to cardiac arrest and sudden death. The disease is associated with mutations in the genes encoding for the cardiac ryanodine receptor (RyR2) and cardiac calsequestrin (CASQ2). CASQ2 mutations lead to a major loss of CASQ2 monomers, possibly because of enhanced degradation of the mutant protein. The decrease...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22298808
DOI: 10.1161/CIRCRESAHA.111.263939

Genes

CASQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias.PMID 22298808Read ↗

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