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Article

Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.

Heart rhythm - 1 Jul 2017

Kurtzwald-Josefson Efrat, Yadin Dor, Harun-Khun Shiraz, Waldman Maayan, Aravot Dan, Shainberg Asher, Eldar Michael, Hochhauser Edith, Arad Michael

Abstract excerpt

BACKGROUND: The recessive form of catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2) is caused by mutations in cardiac calsequestrin (CASQ2), leading to protein deficiency. OBJECTIVES: The aims of this study were to develop a viral-delivered gene therapy for CPVT2 and to determine the relationship between CASQ2 expression and antiarrhythmic efficacy in a murine model. METHODS: We used a murine model...

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Source

Identifiers

PMID: 28336343
DOI: 10.1016/j.hrthm.2017.03.025

Genes

CASQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.PMID 28336343Read ↗

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