Article
Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host.
BMC gastroenterology - 2 May 2018
Strati Francesco, Calabrò Antonio, Donati Claudio, De Felice Claudio, Hayek Joussef, Jousson Olivier, Leoncini Silvia, Renzi Daniela, Rizzetto Lisa, De Filippo Carlotta, Cavalieri Duccio
Abstract excerpt
BACKGROUND: Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-reg mediated responses, thus contributing to the pro-inflammatory status associated with RTT. Furthermore, RTT subjects suffer from an intestinal dysbiosis characterized by an abnormal...
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