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Article

Immune regulation by fungal strain diversity in inflammatory bowel disease.

Nature - 1 Mar 2022

Li Xin V, Leonardi Irina, Putzel Gregory G, Semon Alexa, Fiers William D, Kusakabe Takato, Lin Woan-Yu, Gao Iris H, Doron Itai, Gutierrez-Guerrero Alejandra, DeCelie Meghan B, Carriche Guilhermina M, Mesko Marissa, Yang Chen, Naglik Julian R, Hube Bernhard, Scherl Ellen J, Iliev Iliyan D

Abstract excerpt

The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation1-6. Although aberrant changes in the mycobiota have been linked to several diseases, including inflammatory bowel disease3-9, it is currently unknown whether fungal species captured by deep sequencing represent living...

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Identifiers

PMID: 35296857
DOI: 10.1038/s41586-022-04502-w
PMCID: PMC9166917

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