Article

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells

2025-09-20

Abstract excerpt

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress growth of endogenous fungi in human intestinal organ cultures. In healthy intestine, HMB-PP-stim...

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Literature Corpus work: b814fa35-1d8f-58c5-8a36-60e883685d5f
DOI: 10.1101/2025.09.17.676560

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