Article
P1/P2 genotyping of known and novel null alleles in the P1PK and GLOB histo-blood group systems.
Transfusion - 1 Nov 2013
Westman Julia S, Hellberg Asa, Peyrard Thierry, Hustinx Hein, Thuresson Britt, Olsson Martin L
Abstract excerpt
BACKGROUND: The rare but clinically important null phenotypes of the P1PK and GLOB blood group systems are due to alterations in A4GALT and B3GALNT1, respectively. A recently identified single-nucleotide polymorphism in Exon 2a of A4GALT predicts the common P1 and P2 phenotypes but rare variants have not been tested. STUDY DESIGN AND METHODS: The aim of this study was to analyze 84 p, P1 (k) , and P2 (k) samples,...
Topics
- Alleles
- Blood Donors
- Blood Grouping and Crossmatching
- Cells, Cultured
- Cohort Studies
- Galactosyltransferases
- Gene Silencing
- Genotyping Techniques
- Globosides
- Humans
- Molecular Sequence Data
- N-Acetylgalactosaminyltransferases
- N-Acetylglucosaminyltransferases
- P Blood-Group System
- Phenotype
- Polymorphism, Single Nucleotide