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Article

Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.

Stem cell reports - 5 Jun 2018

Mayerl Steffen, Schmidt Manuel, Doycheva Denica, Darras Veerle M, Hüttner Sören S, Boelen Anita, Visser Theo J, Kaether Christoph, Heuer Heike, von Maltzahn Julia

Abstract excerpt

Thyroid hormone (TH) transporters are required for the transmembrane passage of TH in target cells. In humans, inactivating mutations in the TH transporter MCT8 cause the Allan-Herndon-Dudley syndrome, characterized by severe neuromuscular symptoms and an abnormal TH serum profile, which is fully replicated in Mct8 knockout mice and Mct8/Oatp1c1 double-knockout (M/O DKO) mice. Analysis of tissue TH content and...

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Identifiers

PMID: 29706500
DOI: 10.1016/j.stemcr.2018.03.021
PMCID: PMC5993536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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