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Article

Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination.

EBioMedicine - 1 Nov 2017

Lee Jae Young, Kim Min Joung, Deliyanti Devy, Azari Michael F, Rossello Fernando, Costin Adam, Ramm Georg, Stanley Edouard G, Elefanty Andrew G, Wilkinson-Berka Jennifer L, Petratos Steven

Abstract excerpt

Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits...

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Identifiers

PMID: 29111262
DOI: 10.1016/j.ebiom.2017.10.016
PMCID: PMC5704066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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