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Targets of complement-fixing antibodies in protective immunity against malaria in children

5 Feb 2019

Abstract excerpt

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we show that complement-fixing antibodies to merozoites are more strongly correlated with protective immunity than...

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PMID: 30723225
DOI: 10.1038/s41467-019-08528-z

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