Article
Blastic plasmacytoid dendritic cell neoplasm arising from clonal hematopoiesis.
International journal of hematology - 1 Oct 2018
Suma Sakurako, Sakata-Yanagimoto Mamiko, Nguyen Tran B, Hattori Keiichiro, Sato Taiki, Noguchi Masayuki, Nannya Yasuhito, Ogawa Seishi, Watanabe Rei, Fujimoto Manabu, Nakamura Naoya, Kusakabe Manabu, Nishikii Hidekazu, Kato Takayasu, Chiba Shigeru
Abstract excerpt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cells. The p.D1129fs and p.K1005fs TET2 mutations, p.P95H SRSF2 mutation, and p.L287fs NPM1 mutation...
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