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Clonal evolution and blastic plasmacytoid dendritic cell neoplasm: malignancies of divergent hematopoietic lineages emerging from a common founding clone

18 Jun 2024

Abstract excerpt

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive blood cancer that originates from clonal pDCs or their precursors. A shared clonal origin between BPDCN and syn- and metachronous myeloid neoplasms, is assumed in up to 20% of cases [ 1 ]. Recurrently observed clonal pDCs in chronic myelomonocytic leukemia (CMML) and clonal hematopoiesis (CH) detection in approximately 65% of BPDCN...

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PMID: 38890446
DOI: 10.1038/s41375-024-02305-8

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