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Article

Nuclear progestin receptor (Pgr) knockouts resulted in subfertility in male tilapia (Oreochromis niloticus).

The Journal of steroid biochemistry and molecular biology - 1 Sept 2018

Fang Xuelian, Wu Limin, Yang Lanying, Song Lingyun, Cai Jing, Luo Feng, Wei Jing, Zhou Linyan, Wang Deshou

Abstract excerpt

It was documented that 17α, 20β-dihydroxy-4-pregnen-3-one (DHP), a fish specific progestin, might play critical roles in spermatogenesis, sperm maturation and spermiation partially through activating nuclear receptor (Pgr). However, no direct evidence is available to demonstrate the functions of DHP in fish spermatogenesis. To further elucidate the roles of DHP in teleosts, we generated a pgr homozygous mutant...

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Identifiers

PMID: 29705270
DOI: 10.1016/j.jsbmb.2018.04.011

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PCNA

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