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Article

Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus).

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Jan 2000

Su Yun, Wu You, Ye Maolin, Zhao Chenhua, Li Lu, Cai Jing, Chakraborty Tapas, Yang Lanying, Wang Deshou, Zhou Linyan

Abstract excerpt

Steroidogenic acute regulatory protein (Star) plays an essential role in the biosynthesis of corticosteroids and sex steroids by mediating the transport of cholesterol from the outer to the inner membrane of mitochondria. Two duplicated Star genes, namely star1 and star2, have been identified in non-mammalian vertebrates. To investigate the roles of star genes in fish steriodogenesis, we generated two mutation...

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PMID: 38729293
DOI: 10.1016/j.cbpb.2024.110985

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Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus).PMID 38729293Read ↗

The role of StAR2 gene in testicular differentiation and spermatogenesis in Nile tilapia (Oreochromis niloticus).Semantic proximity Read ↗

Cyp17a1 is Required for Female Sex Determination and Male Fertility by Regulating Sex Steroid Biosynthesis in FishSemantic proximity Read ↗

Clinical spectrum of human STAR variants and their genotype-phenotype correlation.Semantic proximity Read ↗

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Semantic proximity Read ↗

Haploinsufficiency of SF-1 Causes Female to Male Sex Reversal in Nile Tilapia, Oreochromis niloticusSemantic proximity Read ↗

Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and ReproductionSemantic proximity Read ↗

Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1Semantic proximity Read ↗

Nuclear progestin receptor (Pgr) knockouts resulted in subfertility in male tilapia (Oreochromis niloticus).Semantic proximity Read ↗

Developmental Roles of the Steroidogenic Acute Regulatory Protein (StAR) as Revealed by StAR Knockout MiceSemantic proximity Read ↗

Developmental Roles of the Steroidogenic Acute Regulatory Protein (StAR) as Revealed by StAR Knockout MiceSemantic proximity Read ↗

The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein.Semantic proximity Read ↗

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