The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

doi:10.1038/s41467-018-04114-x

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Article

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

Nature communications - 27 Apr 2018

Capper Michael J, Wright Gareth S A, Barbieri Letizia, Luchinat Enrico, Mercatelli Eleonora, McAlary Luke, Yerbury Justin J, O'Neill Paul M, Antonyuk Svetlana V, Banci Lucia, Hasnain S Samar

Abstract excerpt

Superoxide dismutase-1 (SOD1) mutants, including those with unaltered enzymatic activity, are known to cause amyotrophic lateral sclerosis (ALS). Several destabilizing factors contribute to pathogenicity including a reduced ability to complete the normal maturation process which comprises folding, metal cofactor acquisition, intra-subunit disulphide bond formation and dimerization. Immature SOD1 forms toxic...

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Identifiers

PMID: 29703933
DOI: 10.1038/s41467-018-04114-x
PMCID: PMC5923229

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.