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Article

All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia.

Advances in therapy - 1 Jan 2000

Lin Jen-Tsun, Wu Ming-Shiuan, Wang Wei-Shu, Yen Chueh-Chuan, Chiou Tzeon-Jye, Liu Jin-Hwang, Yang Mu-Hua, Chao Ta-Chon, Chou Shu-Chaou, Chen Po-Min

Abstract excerpt

The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 microM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells....

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Identifiers

PMID: 15058751
DOI: 10.1007/BF02849800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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