Article
Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies.
PloS one - 1 Jan 2018
Pande Mala, Joon Aron, Brewster Abenaa M, Chen Wei V, Hopper John L, Eng Cathy, Shete Sanjay, Casey Graham, Schumacher Fredrick, Lin Yi, Harrison Tabitha A, White Emily, Ahsan Habibul, Andrulis Irene L, Whittemore Alice S, John Esther M, Ko Win Aung, Makalic Enes, Schmidt Daniel F, Kapuscinski Miroslaw K, Ochs-Balcom Heather M, Gallinger Steven, Jenkins Mark A, Newcomb Polly A, Lindor Noralane M, Peters Ulrike, Amos Christopher I, Lynch Patrick M
Abstract excerpt
BACKGROUND: Clustering of breast and colorectal cancer has been observed within some families and cannot be explained by chance or known high-risk mutations in major susceptibility genes. Potential shared genetic susceptibility between breast and colorectal cancer, not explained by high-penetrance genes, has been postulated. We hypothesized that yet undiscovered genetic variants predispose to a breast-colorectal...
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