Article
Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children.
The American journal of tropical medicine and hygiene - 1 Jun 2018
Kasule Jingo, Gabriel Erin E, Anok Aggrey, Neal Jillian, Eastman Richard T, Penzak Scott, Newell Kevin, Serwadda David, Duffy Patrick E, Reynolds Steven J, Hobbs Charlotte V
Abstract excerpt
Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis in HIV-uninfected, exposed (HUE) children variably reduces clinical malaria burden despite antifolate resistance, but data regarding achieved serum levels and adherence are lacking. Serum samples from 70 HUE children aged 3-12 months from Rakai, Uganda, enrolled in an observational study were assayed for random SMX levels using a colorimetric assay. Adherence...
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