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Article

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Eziefula Alice C, Pett Helmi, Grignard Lynn, Opus Salome, Kiggundu Moses, Kamya Moses R, Yeung Shunmay, Staedke Sarah G, Bousema Teun, Drakeley Chris

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

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Identifiers

PMID: 24913169
DOI: 10.1128/AAC.02889-14
PMCID: PMC4136063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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