Article
A novel field-based molecular assay to detect validated artemisinin-resistant k13 mutants.
Malaria journal - 24 Apr 2018
Vachot-Ganée Laurence, Khim Nimol, Iannello Alexandra, Legrand Eric, Kim Saorin, Eam Rotha, Khean Chanra, Ken Malen, Ashley Elizabeth, Tun Kyaw Myo, Dhorda Mehul, Nosten François, Souleymane Issa Mahamat, Blein Sophie, Pachot Alexandre, Ariey Frédéric, Kaiser Karine, Ménard Didier
Abstract excerpt
BACKGROUND: Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not available in malaria endemic areas. METHODS: A semi-automated workflow based on the easyMAG®...
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